Prof. dr. Aleksandar Ljubic
Bio IVF represents the first level of ovarian rejuvenation therapy. The foundation of this therapy level is the application of highly concentrated autologous activated platelet-derived growth factors (hc PRP).
Bio IVF Basic includes highly concentrated autologous activated growth factors (hc PRP).
Bio IVF Medium combines hc PRP with a biological autologous fibrin matrix called Bioregenerative Fibrin (BRF).
Bio IVF Advanced adds metabolic optimization through Therapeutic Plasma Exchange (TPE) along with hc PRP and BRF.This therapy is usually done during ovarian stimulation, with intra-ovarian applications performed in the early days of the menstrual cycle.
This procedure is most commonly performed during stimulation when intra-ovarian applications of stimulators occur in the early days of the menstrual cycle.
Bio IVF In Detail
Explore the three levels of Bio IVF Therapy
Bio IVF
Basic
INTRAUTERINE/INTRAOVARIAN hcPRP
The latest generation of autologous activated highly concentrated growth factors (hc PRP) applied to the ovaries and endometrium. Performed as a one-day procedure, on cycle days 2–4.
Bio IVF Basic procedure flow:
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Blood sample collection for growth factor extraction
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Optimization with platelet and growth factor concentration
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Preparation of the autologous activator – thrombin
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Ultrasound-guided intraovarian injections of highly concentrated growth factors (hcPRP); FSH or FSH/LH, GH, and hCG
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Ultrasound-guided administration of autologous activated highly concentrated growth factors (hcPRP) and hCG: transmyometrial, subendometrial, and intracavitary applications
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Reproductive support – SEGOVA medical team
Bio IVF
Medium
INTRAUTERINE/INTRAOVARIAN hcPRP with BRF
The latest generation of autologous activated hcP RP combined with bioregenerative fibrin matrix (BRF) applied to the ovaries and endometrium. One-day procedure, performed on cycle days 2–4.
Bio IVF Medium procedure flow:
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Blood sample collection for growth factor extraction
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Optimization with platelet and growth factor concentration
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Isolation of bioregenerative fibrin
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Preparation of the autologous activator – thrombin
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Ultrasound-guided intraovarian injections of BRF matrix and hcPRP; FSH or FSH/LH, GH, and hCG
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Ultrasound-guided administration of hcPRP and hCG: transmyometrial, subendometrial with BRF matrix, and intracavitary applications
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Reproductive support – SEGOVA medical team
Bio IVF
Advanced
INTRAUTERINE/INTRAOVARIAN hcPRP with BRF & TPE
Therapeutic Plasma Exchange (TPE) combined with the hcPRP and BRF applied to the ovaries and endometrium.
Procedure details: One-day procedure, performed on cycle days 2–4.
Bio IVF Advanced Procedure Flow:
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TPE Procedure: Vascular access; Extracorporeal blood circulation; Plasma removal; Repla-cement with adjuvants; Centrifugation and re-infusion
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Blood sample collection for growth factor extraction
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Optimization of hc PRP
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Isolation of BRF
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Preparation of the thrombin
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US guided intraovarian injections of BRF; hc PRP; FSH or FSH/LH, GH; hCG
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US guided transmyometrial, subendometrial and intrauterine injections of hc PRP; hCG; BRF
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Reproductive support